{"id":749,"date":"2025-05-09T17:53:36","date_gmt":"2025-05-09T17:53:36","guid":{"rendered":"https:\/\/st-therapeutics.com\/?p=749"},"modified":"2026-06-22T06:56:26","modified_gmt":"2026-06-22T06:56:26","slug":"novel-therapeutic-approach-could-eliminate-excessive-scarring-following-orofacial-cleft-repair","status":"publish","type":"post","link":"https:\/\/st-therapeutics.com\/zh\/novel-therapeutic-approach-could-eliminate-excessive-scarring-following-orofacial-cleft-repair\/","title":{"rendered":"\u65b0\u578b\u6cbb\u7642\u7b56\u7565\u6709\u671b\u6d88\u9664\u5507\u984e\u88c2\u4fee\u5fa9\u624b\u8853\u5f8c\u7684\u904e\u5ea6\u75a4\u75d5"},"content":{"rendered":"
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Skylar Rolstad <\/a>May 9, 2025 <\/a>Posted in News<\/a>, Research News<\/a>
Tags:Craniofacial Biology<\/a><\/p>\n\t\t\n<\/div>\n

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\n\t\thttps:\/\/forsyth.org\/novel-therapeutic-approach-could-eliminate-excessive-scarring-following-orofacial-cleft-repair\/\n\t<\/a><\/p>\n\t\t\t\t\t

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Somerville, Mass., 05\/07\/2025 \u2013 <\/strong>Cleft lip and\/or cleft palate are among the most common craniofacial birth defects in the United States. These conditions, collectively referred to as orofacial clefts, occur when a baby\u2019s lip or mouth do not form properly during pregnancy. 

\u7576\u53e3\u984f\u88c2\u900f\u904e\u624b\u8853\u9032\u884c\u4fee\u5fa9\u6642\uff0c\u5e38\u6703\u7522\u751f\u4e00\u7a2e\u9686\u8d77\u4e14\u589e\u539a\u7684\u75a4\u75d5\uff0c\u7a31\u70ba \u80a5\u539a\u6027\u75a4\u75d5\uff08hypertrophic scar\uff09\u3002\u6b64\u985e\u75a4\u75d5\u53ef\u80fd\u9020\u6210\u5916\u89c0\u8b8a\u5f62\u4e26\u5f71\u97ff\u529f\u80fd\uff0c\u5c0d\u60a3\u8005\u5e36\u4f86\u91cd\u5927\u7684\u793e\u6703\u8207\u7d93\u6fdf\u5f71\u97ff\u3002 

\u8fd1\u671f\u7531 ADA Forsyth Institute\uff08AFI\uff09 \u8207 \u52a0\u5dde\u5927\u5b78\u6d1b\u6749\u78ef\u5206\u6821\uff08UCLA\uff09 \u79d1\u5b78\u5bb6\u5408\u4f5c\u9032\u884c\u7684\u4e00\u9805\u7814\u7a76\u6307\u51fa\uff0c\u4e00\u7a2e\u524d\u6cbf\u7684\u65b0\u578b\u6cbb\u7642\u65b9\u6cd5\u53ef\u80fd\u80fd\u5920\u6e1b\u8f15\u751a\u81f3\u9810\u9632\u904e\u5ea6\u75a4\u75d5\u5f62\u6210\uff0c\u70ba\u50b7\u53e3\u7652\u5408\u8207\u518d\u751f\u91ab\u5b78\u9818\u57df\u5e36\u4f86\u91cd\u8981\u7a81\u7834 

Scars are an important part of the body\u2019s natural response to injury to wall off the injured site from normal tissues.\u202fDuring healing, scars are replaced gradually with healthy tissues. However, in abnormal healing, excessive myofibroblasts \u2013 cells that produce and organize collagen and play a key role in wound healing \u2013 and other abnormal activities can lead to excess scarring that does not heal normally. 

\u7814\u7a76\u5718\u968a\u6210\u54e1\u5305\u62ec AFI \u517c\u4efb\u6559\u5e2b Eric Kang Ting<\/u><\/strong><\/a>, D.M.D., D.Med.Sc.\uff0c\u4ee5\u53ca UCLA \u7814\u7a76\u4eba\u54e1 Chia Soo, M.D.<\/u><\/strong><\/a>, Pin Ha, D.D.S., M.D.<\/u><\/strong><\/a>\u4ee5\u53ca Zhong Zheng, Ph.D.<\/u><\/strong><\/a> identified a molecule \u2013 fibromodulin (FMOD) protein \u2013 which works to maintain a balanced level of myofibroblasts, resulting in minimal scarring at the surgical site. The scientists detail this mechanism in a new paper published in <\/u>Nature Communications<\/u><\/em><\/strong><\/a>. 

\u4e01\u91ab\u5e2b\u8868\u793a\uff1a\n\u300c\u6211\u5011\u7684\u7814\u7a76\u5718\u968a\u4e00\u76f4\u5728\u63a2\u7d22\u5982\u4f55\u6539\u5584\u5507\u88c2\u4fee\u5fa9\u624b\u8853\u5f8c\u7684\u75a4\u75d5\u554f\u984c\u3002\u6211\u5011\u5df2\u767c\u73fe\u4e00\u7a2e\u6e90\u81ea fibromodulin \u7684\u65b0\u578b\u80dc\u80bd\u85e5\u7269\uff0c\u53ef\u80fd\u6709\u52a9\u65bc\u6e1b\u5c11\u75a4\u75d5\u5f62\u6210\u3002\u672c\u7814\u7a76\u9032\u4e00\u6b65\u8b49\u660e fibromodulin \u5728\u8abf\u63a7\u8207\u75a4\u75d5\u5f62\u6210\u76f8\u95dc\u7684\u95dc\u9375\u7d30\u80de\u2014\u2014\u808c\u6210\u7e96\u7dad\u7d30\u80de\u2014\u2014\u65b9\u9762\u5177\u6709\u66f4\u5ee3\u6cdb\u7684\u91cd\u8981\u4f5c\u7528\u3002\u300d <\/p>\n\t\t\t\t\t

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\u3000<\/p>\n\t\t\t\t\t\"\"\/\t\t\t\t\t

\u3000
\u5728\u5982\u5507\u88c2\u7e2b\u5408\u7b49\u7d44\u7e54\u9589\u5408\u624b\u8853\u4e2d\u52a0\u5165 FMOD\uff08fibromodulin\uff09\uff0c\u53ef\u9632\u6b62\u904e\u5ea6\u75a4\u75d5\u5f62\u6210\u3002\u6b64\u65b9\u6cd5\u4ea6\u53ef\u80fd\u6210\u529f\u9810\u9632\u87f9\u8db3\u816b\uff08keloid scars\uff09\u7684\u7522\u751f\u3002\u87f9\u8db3\u816b\u662f\u4e00\u7a2e\u75a4\u75d5\u985e\u578b\uff0c\u5176\u7279\u5fb5\u70ba\u75a4\u75d5\u7d44\u7e54\u904e\u5ea6\u751f\u9577\uff0c\u4e26\u8d85\u51fa\u539f\u59cb\u50b7\u53e3\u908a\u754c\u3002 

\u201cBy targeting the biology of scarring at the molecular level, this breakthrough has the potential to transform outcomes for patients undergoing cleft repair and other surgical procedures,\u201d said AFI chief science officer and chief operating officer .<\/u><\/strong><\/a>. \u201cThis powerful translational science brings fundamental biological insights to clinical care and would not have been possible without critical funding support by NIH.\u201d 

\u8607\u91ab\u5e2b\u8868\u793a\uff1a\n\u300c\u4e01\u91ab\u5e2b\u8207\u6211\u5728\u904e\u53bb\u4e8c\u5341\u5e74\u4e00\u76f4\u81f4\u529b\u65bc\u7814\u7a76\u5982\u4f55\u6e1b\u5c11\u76ae\u819a\u75a4\u75d5\u3002\u9019\u9805\u6700\u65b0\u7a81\u7834\u8aaa\u660e fibromodulin \u53ef\u900f\u904e\u53d7\u63a7\u5236\u7684\u7d30\u80de\u6b7b\u4ea1\uff08controlled cell death\uff09\u4f86\u6e1b\u5c11\u904e\u5ea6\u75a4\u75d5\u5f62\u6210\uff0c\u986f\u793a\u5728\u6cbb\u7642\u904e\u5ea6\u75a4\u75d5\u60a3\u8005\u65b9\u9762\u5177\u6709\u91cd\u5927\u6f5b\u529b\u3002\u300d  

\u9019\u9805\u7814\u7a76\u70ba\u76ae\u819a\u50b7\u53e3\u4fee\u5fa9\uff08cutaneous wound repair\uff09\u9818\u57df\u63d0\u4f9b\u4e86\u65b0\u7684\u89c0\u9ede\uff0c\u671d\u5411\u6e1b\u5c11\u75a4\u75d5\u5f62\u6210\u4e26\u6539\u5584\u81e8\u5e8a\u6cbb\u7642\u7d50\u679c\u7684\u65b9\u5411\u767c\u5c55\u3002\n\u912d\u535a\u58eb\u76ee\u524d\u6b63\u4e3b\u6301\u4e00\u9805FDA \u6838\u51c6\u7684\u81e8\u5e8a\u7814\u7a76\uff08Phase 1\/2A\uff09\uff0c\u8a55\u4f30 fibromodulin \u884d\u751f\u80dc\u80bd\uff08fibromodulin-derived peptide\uff09 \u7684\u6cbb\u7642\u6548\u679c\u3002 

\u912d\u535a\u58eb\u8868\u793a\uff1a\u300c\u5728\u672c\u7814\u7a76\u4e2d\uff0c\u6211\u5011\u8b49\u660e fibromodulin\uff08\u5c6c\u65bc\u4e00\u7a2e matricellular proteoglycan\uff09\u53ef\u5728\u4e0d\u5e72\u64fe\u521d\u671f\u50b7\u53e3\u4fee\u5fa9\u7684\u60c5\u6cc1\u4e0b\uff0c\u52a0\u901f\u808c\u6210\u7e96\u7dad\u7d30\u80de\uff08myofibroblasts\uff09\u7684\u6e05\u9664\uff0c\u5f9e\u800c\u63d0\u4f9b\u4e00\u7a2e\u65b0\u7684\u6e1b\u5c11\u75a4\u75d5\u5f62\u6210\u6a5f\u5236\u3002\u300d 

\u7814\u7a76\u7d93\u8cbb<\/strong> 
This work was funded by NIH NIDCR R44DE024692 (to C.S. and Z.Z.) and SB1DE026972 (to K.T., C.S., and Z.Z.); NIH NIAMS R44AR064126 (to C.S. and Z.Z.), UCLA CTSI grant UL1TR000124 (to C.S.), UCLA Operation Mend (to C.S.), UCLA Orthopaedic Hospital (to C.S.), UCLA Orthopaedic Hospital Research Center (to C.S.), and the International Orthodontics Foundation. 

\u8ad6\u6587\u5f15\u7528 <\/strong> 
\u201cFibromodulin selectively accelerates myofibroblast apoptosis in cutaneous wounds by enhancing interleukin 1\u03b2 signaling,\u201d Nature Communications<\/em>. DOI#1038\/s41467-025-58906-z 

\u95dc\u65bc ADA Forsyth Institute<\/strong> 
The ADA Forsyth Institute<\/u><\/a> was founded in 1910 as the Forsyth Dental Infirmary for Children (later, the Forsyth Institute), to provide dental care to the disadvantaged children of Boston. While continuing to serve children in need, yet recognizing the ultimate goal is to prevent dental disease, the Institute in 1915 began to focus on scientific research and is today the world\u2019s leader in oral health research. In October of 2023, the Institute joined with the American Dental Association to form the ADA Forsyth Institute, a 501(c)(3) entity dedicated to improving people\u2019s oral and overall health and powering the profession of dentistry through cutting-edge basic research, creative translational science, innovative clinical technologies, and global public health outreach.\u202fConsistent with the Institute\u2019s founding mission, the ADA ForsythKids mobile dental program continues to serve children in need.

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\u3000 Novel therapeutic approach could eliminate excessive scarring following orofacial cleft repair Skylar Rolstad May 9, 2025 Posted in News, Research NewsTags:Craniofacial Biology Novel therapeutic approach could eliminate excessive scarring following orofacial cleft repair \u3000 Somerville, Mass., 05\/07\/2025 \u2013 Cleft lip and\/or cleft palate are among the most common craniofacial birth defects in the United […]<\/p>\n","protected":false},"author":6,"featured_media":750,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_angie_page":false,"cybocfi_hide_featured_image":"yes","page_builder":"","footnotes":""},"categories":[26],"tags":[],"class_list":["post-749","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/st-therapeutics.com\/zh\/wp-json\/wp\/v2\/posts\/749","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/st-therapeutics.com\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/st-therapeutics.com\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/st-therapeutics.com\/zh\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/st-therapeutics.com\/zh\/wp-json\/wp\/v2\/comments?post=749"}],"version-history":[{"count":13,"href":"https:\/\/st-therapeutics.com\/zh\/wp-json\/wp\/v2\/posts\/749\/revisions"}],"predecessor-version":[{"id":960,"href":"https:\/\/st-therapeutics.com\/zh\/wp-json\/wp\/v2\/posts\/749\/revisions\/960"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/st-therapeutics.com\/zh\/wp-json\/wp\/v2\/media\/750"}],"wp:attachment":[{"href":"https:\/\/st-therapeutics.com\/zh\/wp-json\/wp\/v2\/media?parent=749"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/st-therapeutics.com\/zh\/wp-json\/wp\/v2\/categories?post=749"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/st-therapeutics.com\/zh\/wp-json\/wp\/v2\/tags?post=749"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}