{"id":737,"date":"2025-04-30T16:20:28","date_gmt":"2025-04-30T16:20:28","guid":{"rendered":"https:\/\/st-therapeutics.com\/?p=737"},"modified":"2026-06-22T06:48:21","modified_gmt":"2026-06-22T06:48:21","slug":"researchers-may-have-found-a-way-to-mitigate-or-eliminate-excessive-scarring-during-wound-healing","status":"publish","type":"post","link":"https:\/\/st-therapeutics.com\/zh\/researchers-may-have-found-a-way-to-mitigate-or-eliminate-excessive-scarring-during-wound-healing\/","title":{"rendered":"Researchers may have found a way to mitigate or eliminate excessive scarring during wound healing"},"content":{"rendered":"
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Researchers may have found a way to mitigate or eliminate excessive scarring during wound healing<\/h2>\n\t\t\n<\/div>\n
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EurekAlert!\u25b8Peer-Reviewed Publication<\/a><\/p>\n\t\t\n<\/div>\n

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University of California - Los Angeles Health Sciences<\/p>\n\t\t\n<\/div>\n

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News Release 30-Apr-2025<\/strong><\/p>\n\t\t\n<\/div>\n

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\n\t\thttps:\/\/www.eurekalert.org\/news-releases\/1082760\n\t<\/a><\/p>\n\t\t\t\t\t

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\u4e00\u9805\u65bc 4 \u6708 12 \u65e5\u767c\u8868\u65bc Nature Communications<\/em> \u7684\u7814\u7a76\u6307\u51fa\uff0c\u4e00\u7a2e\u86cb\u767d\u8cea\u53ef\u80fd\u6709\u52a9\u65bc\u9632\u6b62\u904e\u5ea6\u75a4\u75d5\u5f62\u6210\u3002\u8a72\u86cb\u767d\u8cea\u7a31\u70ba fibromodulin\uff08FMOD\uff09\uff0c\u53ef\u8207 interleukin-1\u03b2\u5f62\u6210\u5206\u5b50\u8907\u5408\u9ad4\uff0c\u6291\u5236 \u808c\u6210\u7e96\u7dad\u7d30\u80de\uff08myofibroblasts\uff09 \u7522\u751f\u904e\u91cf\u7684\u75a4\u75d5\u7d44\u7e54\u3002<\/p>\n\t\t\t\t\t

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\u6b64\u7814\u7a76\u7d50\u679c\u53ef\u80fd\u4fc3\u6210\u65b0\u7684\u6cbb\u7642\u7b56\u7565\uff0c\u7528\u4ee5\u964d\u4f4e\u6216\u9810\u9632\u904e\u5ea6\u75a4\u75d5\u7684\u5f62\u6210\uff0c\u5c0d\u65bc\u56e0\u624b\u8853\u3001\u5916\u50b7\u6216\u71d2\u71d9\u50b7\u800c\u6062\u5fa9\u4e2d\u7684\u60a3\u8005\u5177\u6709\u6f5b\u5728\u81e8\u5e8a\u76ca\u8655\u3002<\/p>\n\t\t\t\t\t

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Photo Credit: Joshua Sudock<\/p>\n\t\t\n<\/div>\n

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BACKGROUND<\/p>\n\t\t\t\t\t

In previous studies, the researchers had described the critical role of FMOD in enabling scarless fetal-type repair as well as preventing excessive scarring during adult-type repair. For this new study, the researchers investigated the effects of FMOD on myofibroblasts, a key cell in healing and scar formation. Myofibroblasts should die off after a wound heals, but they can continue forming tissue long afterwards, leading to excessive scarring.  The fibromodulin-based complex promotes the death of myofibroblasts.<\/p>\n\t\t\t\t\t

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COMMENT<\/p>\n\t\t\t\t\t

\u201cDr. Eric Kang Ting and I have been studying how to reduce skin scarring for the past two decades at UCLA,\u201d said Dr. Chia Soo, professor of surgery and vice chair for research for the UCLA Division of Plastic and Reconstructive Surgery.  \u201cThis publication explores the crucial role of naturally occurring fibromodulin in regulating a key scar-forming cell, the myofibroblast. This, combined with our team\u2019s FDA-approved clinical study led by Dr. Zhong Zheng using a fibromodulin-derived peptide in 54 patients for scar reduction, demonstrates a significant leap in potential treatments for patients with excessive scarring.\u201d<\/p>\n\t\t\t\t\t

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Study co-authors are Wenlu Jiang, Xiaoxiao Pang, Pin Ha, Chenshuang Li, Grace Xinlian Chang, Yuxin Zhang, and Lawrence A. Bossong, Eric Kang Ting, and Zhong Zheng.<\/p>\n\t\t\t\t\t

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FUNDING<\/p>\n\t\t\t\t\t

\u2022\t\u7f8e\u570b \u570b\u5bb6\u7259\u79d1\u8207\u9871\u984f\u7814\u7a76\u9662\uff08National Institute of Dental and Craniofacial Research\uff09\n\u2022\t\u7f8e\u570b \u570b\u5bb6\u95dc\u7bc0\u708e\u3001\u808c\u8089\u9aa8\u9abc\u8207\u76ae\u819a\u75be\u75c5\u7814\u7a76\u9662\uff08National Institute of Arthritis and Musculoskeletal and Skin Diseases\uff09\n\u2022\tUCLA \u81e8\u5e8a\u8207\u8f49\u8b6f\u79d1\u5b78\u7814\u7a76\u6240\uff08CTSI\uff09\uff08UL1TR000124\uff09\n\u2022\tUCLA Operation Mend\n\u2022\tUCLA Orthopaedic Hospital\n\u2022\tUCLA Orthopaedic Hospital Research Center\n\u2022\tInternational Orthodontics Foundation\n\u2022\t\u4e2d\u570b\u535a\u58eb\u5f8c\u79d1\u5b78\u57fa\u91d1\n\u2022\t\u4e2d\u570b\u91cd\u6176\u5e02\u81ea\u7136\u79d1\u5b78\u57fa\u91d1\n\u2022\t\u91cd\u6176\u91ab\u79d1\u5927\u5b78\u672a\u4f86\u91ab\u5b78\u9752\u5e74\u5275\u65b0\u8a08\u756b<\/p>\n\t\t\t\t\t

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\u5229\u76ca\u63ed\u9732<\/p>\n\t\t\t\t\t

Eric Kang Ting\u3001Chia Soo \u8207 Zhong Zheng \u70ba fibromodulin \u76f8\u95dc\u5c08\u5229\uff08\u7531 UCLA \u6307\u6d3e\uff09\u7684\u767c\u660e\u4eba\u3002\u4ed6\u5011\u4ea6\u5275\u7acb Scarless Laboratories Inc. \u8207 Saint Therapeutics Inc.\u3002\u9019\u5169\u5bb6\u516c\u53f8\u81ea \u52a0\u5dde\u5927\u5b78\u8463\u4e8b\u6703\uff08UC Regents\uff09 \u53d6\u5f97 fibromodulin \u76f8\u95dc\u5c08\u5229\u7684\u518d\u6388\u6b0a\uff0c\u800c UC Regents \u540c\u6642\u6301\u6709\u8a72\u516c\u53f8\u80a1\u6b0a\u3002\u6b64\u5916\uff0c\u4e0a\u8ff0\u7814\u7a76\u4eba\u54e1\u76ee\u524d\u6216\u66fe\u4efb Scarless Laboratories Inc. \u8207 Saint Therapeutics Inc. \u7684\u7ba1\u7406\u8077\u4f4d\u3002 <\/p>\n\t\t\n<\/div>\n\t\t<\/div>","protected":false},"excerpt":{"rendered":"

\u3000 Researchers may have found a way to mitigate or eliminate excessive scarring during wound healing EurekAlert!\u25b8Peer-Reviewed Publication University of California – Los Angeles Health Sciences News Release 30-Apr-2025 https:\/\/www.eurekalert.org\/news-releases\/1082760 \u3000 \u3000 FINDINGS A study published April 12 in Nature Communications identifies a protein that helps prevent excessive scarring. The protein, called fibromodulin (FMOD) forms […]<\/p>\n","protected":false},"author":6,"featured_media":492,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_angie_page":false,"cybocfi_hide_featured_image":"yes","page_builder":"","footnotes":""},"categories":[26],"tags":[],"class_list":["post-737","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/st-therapeutics.com\/zh\/wp-json\/wp\/v2\/posts\/737","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/st-therapeutics.com\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/st-therapeutics.com\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/st-therapeutics.com\/zh\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/st-therapeutics.com\/zh\/wp-json\/wp\/v2\/comments?post=737"}],"version-history":[{"count":20,"href":"https:\/\/st-therapeutics.com\/zh\/wp-json\/wp\/v2\/posts\/737\/revisions"}],"predecessor-version":[{"id":957,"href":"https:\/\/st-therapeutics.com\/zh\/wp-json\/wp\/v2\/posts\/737\/revisions\/957"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/st-therapeutics.com\/zh\/wp-json\/wp\/v2\/media\/492"}],"wp:attachment":[{"href":"https:\/\/st-therapeutics.com\/zh\/wp-json\/wp\/v2\/media?parent=737"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/st-therapeutics.com\/zh\/wp-json\/wp\/v2\/categories?post=737"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/st-therapeutics.com\/zh\/wp-json\/wp\/v2\/tags?post=737"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}