{"id":264,"date":"2021-07-14T15:03:54","date_gmt":"2021-07-14T15:03:54","guid":{"rendered":"https:\/\/host1online.com\/ScarlessLabs\/?page_id=264"},"modified":"2025-12-16T21:15:19","modified_gmt":"2025-12-16T21:15:19","slug":"our-science","status":"publish","type":"page","link":"https:\/\/st-therapeutics.com\/zh\/our-science\/","title":{"rendered":"\u79d1\u5b78\u7814\u7a76"},"content":{"rendered":"<h1>\u6280\u8853<\/h1>\n\t<meta itemprop=\"url\" content=\"https:\/\/st-therapeutics.com\/wp-content\/uploads\/2021\/07\/FMOD_camera-spin.mp4\" \/><div style=\"width: 640px;\" class=\"wp-video\"><video class=\"wp-video-shortcode\" id=\"video-264-1\" width=\"640\" height=\"360\" loop autoplay preload=\"metadata\" controls=\"controls\"><source type=\"video\/mp4\" src=\"https:\/\/st-therapeutics.com\/wp-content\/uploads\/2021\/07\/FMOD_camera-spin.mp4?_=1\" \/><a href=\"https:\/\/st-therapeutics.com\/wp-content\/uploads\/2021\/07\/FMOD_camera-spin.mp4\">https:\/\/st-therapeutics.com\/wp-content\/uploads\/2021\/07\/FMOD_camera-spin.mp4<\/a><\/video><\/div>\n<p>SLI-F06 is based on over 20 years of research into scar-free fetal wound models. This work led to the discovery of a novel fibromodulin (FMOD)-based peptide that targets scars before they form. SLI-F06 is a synthetic peptide drug that reproduces FMOD&#8217;s anti-scar effects.<\/p>\n\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" src=\"https:\/\/st-therapeutics.com\/wp-content\/uploads\/2025\/09\/\u622a\u5716-2025-09-24-\u4e2d\u534812.49.16.png\" alt=\"\u622a\u5716 2025-09-24 \u4e2d\u534812.49.16\" itemprop=\"image\" height=\"1116\" width=\"2224\" title=\"\u622a\u5716 2025-09-24 \u4e2d\u534812.49.16\" onerror=\"this.style.display='none'\"  \/>\nInspired by rapidly migrating, highly contractile cells in fetal wounds that heal without scarring, Professors Chia Soo, Kang Ting, and Zhong Zheng spent over 20 years uncovering the critical role of fibromodulin (FMOD) in tissue regeneration.\nFMOD promotes Smad-driven (canonical) TGF\u03b21-induced cell migration and contraction while inhibiting non-Smad-driven (non-canonical) TGF\u03b21-induced extracellular matrix production, enabling rapid wound closure and reducing scar formation.\nFMOD also accelerates interleukin (IL)1\u03b2-IL1 receptor complex formation, enhancing apoptosis of myofibroblasts in keloid- and hypertrophic-scar-derived cells. By dampening TGF\u03b21&#8217;s non-Smad pathways, FMOD mitigates excessive fibroblast survival &#8211; a hallmark of fibrosis.\nAs a result, fibromodulin represents a promising broad-spectrum anti-fibrotic therapeutic.\n\t\t\t\t<img decoding=\"async\" src=\"https:\/\/st-therapeutics.com\/wp-content\/uploads\/2021\/07\/sli-fo6.jpg\" alt=\"\" itemprop=\"image\" height=\"304\" width=\"500\" onerror=\"this.style.display='none'\"  \/>\n<p>After intense study of FMOD&#8217;s structure and function, SLI-F06 was created as a synthetic peptide drug to specifically mimic FMOD&#8217;s dual effects to both promote and inhibit TGF\u03b21 signaling to reduce scar and to promote healing. SLI-F06 activates fibroblasts, the main cell-type responsible for skin and soft tissue healing. As a result, fibroblasts get to the wound faster to start healing faster to lessen the wound gap. SLI-F06- activated fibroblasts also differentiate faster into myofibroblasts to start contracting the wound to make it heal faster and stronger (higher breaking strength) and contracting the scar to make it smaller. At the same time, SLI-F06 also reduces ECM production to reduce scar tissue formation.<\/p>","protected":false},"excerpt":{"rendered":"<p>Technology SLI-F06 is based on over 20 years of research into scar-free fetal wound models. This work led to the discovery of a novel fibromodulin (FMOD)-based peptide that targets scars before they form. SLI-F06 is a synthetic peptide drug that reproduces FMOD&#8217;s anti-scar effects. Inspired by rapidly migrating, highly contractile cells in fetal wounds that [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"custom-templates\/100-width.php","meta":{"_angie_page":false,"cybocfi_hide_featured_image":"","footnotes":""},"class_list":["post-264","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/st-therapeutics.com\/zh\/wp-json\/wp\/v2\/pages\/264","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/st-therapeutics.com\/zh\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/st-therapeutics.com\/zh\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/st-therapeutics.com\/zh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/st-therapeutics.com\/zh\/wp-json\/wp\/v2\/comments?post=264"}],"version-history":[{"count":18,"href":"https:\/\/st-therapeutics.com\/zh\/wp-json\/wp\/v2\/pages\/264\/revisions"}],"predecessor-version":[{"id":486,"href":"https:\/\/st-therapeutics.com\/zh\/wp-json\/wp\/v2\/pages\/264\/revisions\/486"}],"wp:attachment":[{"href":"https:\/\/st-therapeutics.com\/zh\/wp-json\/wp\/v2\/media?parent=264"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}